C₁₄H₁₂F₂N₆

Base Information

• Chemical Name: C₁₄H₁₂F₂N₆
• CAS No.: 1436870-02-8
• Molecular Formula: C₁₄H₁₂F₂N₆
• Molecular Weight: 302.286
• Mol file: 1436870-02-8.mol

Synonyms:C₁₄H₁₂F₂N₆

Chemical Property of C₁₄H₁₂F₂N₆

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₄H₁₂F₂N₆

There total 5 articles about C₁₄H₁₂F₂N₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide) (1436870-30-2) → C14H12F2N6 (1436870-02-8)

Guidance literature:

With ammonia; In methanol; dichloromethane; at 20 ℃; Autoclave;

DOI:10.1021/jm400086g

Reference yield:

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine (152941-69-0) → C14H12F2N6 (1436870-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 8 h / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Sealed tube

3: ammonia / dichloromethane; methanol / 20 °C / Autoclave

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonia; lithium hexamethyldisilazane; In methanol; dichloromethane; toluene; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm400086g

Reference yield:

2,5-difluoroaniline (367-30-6) → C14H12F2N6 (1436870-02-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / methanol / 5 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Sealed tube

4: ammonia / dichloromethane; methanol / 20 °C / Autoclave

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonia; sodium methylate; lithium hexamethyldisilazane; In methanol; dichloromethane; toluene; 3: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm400086g

upstream raw materials:

N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine

2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine

2,5-difluoro-N-methylaniline