3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

Base Information

Chemical Name:3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile
CAS No.:157337-07-0
Molecular Formula:C₁₂H₁₄F₂N₂O
Molecular Weight:240.253
Hs Code.:

Synonyms:3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

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Chemical Property of 3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

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Technology Process of 3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

There total 3 articles about 3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 7677-24-9
trimethylsilyl cyanide

: 157337-06-9
2-((1,3-difluoropropan-2-ylidene)amino)-2-phenylethanol

: 157337-07-0
3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

Guidance literature:: In ethanol; at 78 ℃; for 48h;
DOI:10.1055/s-1994-25552

Reference yield:

: 2835-06-5
phenylglycin

: 157337-07-0
3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄

2: 100 percent / benzene / 3 h / 80 °C

3: 96 percent / ethanol / 48 h / 78 °C

With lithium aluminium tetrahydride; In ethanol; benzene;
DOI:10.1055/s-1994-25552

Reference yield:

: 20989-17-7,56613-80-0,71006-16-1,7568-92-5,188586-38-1
Phenylglycinol

: 157337-07-0
3-fluoro-2-(fluoromethyl)-2-((2-hydroxy-1-phenylethyl)amino)-propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / benzene / 3 h / 80 °C

2: 96 percent / ethanol / 48 h / 78 °C

In ethanol; benzene;
DOI:10.1055/s-1994-25552