2-(Trimethylsilyl)ethyl acetate

Base Information

• Chemical Name: 2-(Trimethylsilyl)ethyl acetate
• CAS No.: 16046-10-9
• Molecular Formula: C7H16 O2 Si
• Molecular Weight: 160.288
• Hs Code.: 2931900090
• European Community (EC) Number: 240-189-9
• DSSTox Substance ID: DTXSID80884865
• Nikkaji Number: J219.949A
• Wikidata: Q82863509
• ChEMBL ID: CHEMBL46790
• Mol file: 16046-10-9.mol

Synonyms:2-(trimethylsilyl)ethyl acetate;TMSEA

Chemical Property of 2-(Trimethylsilyl)ethyl acetate

Chemical Property:

• Vapor Pressure: 2.97mmHg at 25°C
• Boiling Point: 155.9°Cat760mmHg
• Flash Point: 40.2°C
• PSA: 26.30000
• Density: 0.874g/cm³
• LogP: 1.88770
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 160.091956283
• Heavy Atom Count: 10
• Complexity: 115

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC[Si](C)(C)C

Technology Process of 2-(Trimethylsilyl)ethyl acetate

There total 6 articles about 2-(Trimethylsilyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + acetic anhydride (108-24-7) → 2-(trimethylsilyl)ethyl acetate (16046-10-9)

Guidance literature:

zinc(II) perchlorate; at 20 ℃; for 3h;

DOI:10.1002/ejoc.200300458

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) + acetyl chloride (75-36-5) → 2-(trimethylsilyl)ethyl acetate (16046-10-9)

Guidance literature:

With pyridine;

DOI:10.1016/S0022-328X(00)93802-6

Reference yield:

Ketene (463-51-4) + 2-(Trimethylsilyl)ethanol (2916-68-9) → 2-(trimethylsilyl)ethyl acetate (16046-10-9)

Guidance literature:

upstream raw materials:

Ketene

2-(Trimethylsilyl)ethanol

acetyl chloride

acetic anhydride

Downstream raw materials:

2-(trimethylsilyl)ethyl (4R)-4-[tert-butoxycarbonyl(methyl)amino]-5-(4-methoxyphenyl)-3-oxopentanoate

3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

5-ethyl 1-methyl 2-benzylidene-4-(trimethylsilyl)pentanedioate

7-ethyl 1-methyl (E)-2-benzylidene-4-methoxycarbonyl-4,6-bis(trimethylsilyl)heptanedioate

Refernces

• 1、 Preindl, Johannes,Jouvin, Kvin,Laurich, Daniel,Seidel, Günter,Fürstner, Alois. "Gold- or Silver-Catalyzed Syntheses of Pyrones and Pyridine Derivatives: Mechanistic and Synthetic Aspects". supporting information. p. 237 - 247. Retrieved 2016/01/25.
• 2、 Bartoli, Giuseppe,Bosco, Marcella,Dalpozzo, Renato,Marcantoni, Enrico,Massaccesi, Massimo,Sambri, Letizia. "Zn(ClO4)2·6H2O as a Powerful Catalyst for a Practical Acylation of Alcohols with Acid Anhydrides". . p. 4611 - 4617. Retrieved 2007/10/03.