allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

Base Information

Chemical Name:allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate
CAS No.:1318165-60-4
Molecular Formula:C₂₆H₂₇NO₇
Molecular Weight:465.503
Hs Code.:

Synonyms:allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

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Chemical Property of allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

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Technology Process of allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

There total 5 articles about allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1063714-86-2
6-(3',5'-dimethoxyphenyl)-2H-chromen-2-one

: 107-18-6
allyl alcohol

: 105-56-6
ethyl 2-cyanoacetate

: 1318165-60-4
allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: ethyl 2-cyanoacetate; With sodium; allyl alcohol; at 20 ℃; for 0.5h; Inert atmosphere;

6-(3',5'-dimethoxyphenyl)-2H-chromen-2-one; allyl alcohol; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200764t

Reference yield:

: 1761-61-1
5-bromosalicyclaldehyde

: 1318165-60-4
allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 24 h / 20 °C

2.1: trichlorophosphate / dichloromethane / 4 h / 80 °C

2.2: 1 h / 60 °C

3.1: sodium / 2 h / 20 °C

With palladium diacetate; sodium; potassium carbonate; triphenylphosphine; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; water; 1.1: Suzuki coupling;
DOI:10.1021/jm300515q

Reference yield:

: 19063-55-9
6-bromo-2H-chromen-2-one

: 1318165-60-4
allyl 4-(2-(allyloxy)-2-oxoethyl)-2-amino-6-(3,5-dimethoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 80 °C

2: sodium / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium; potassium carbonate; In water; toluene; 1: Suzuki coupling;
DOI:10.1021/jm300515q