C₁₈H₂₅NO₄S

Base Information

• Chemical Name: C₁₈H₂₅NO₄S
• CAS No.: 1195778-44-9
• Molecular Formula: C₁₈H₂₅NO₄S
• Molecular Weight: 351.467
• Mol file: 1195778-44-9.mol

Synonyms:C₁₈H₂₅NO₄S

Chemical Property of C₁₈H₂₅NO₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₅NO₄S

There total 5 articles about C₁₈H₂₅NO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C10H18NO2S(1+)*ClO4(1-) (1195778-17-6) + 4-methoxy-benzaldehyde (123-11-5) → C18H25NO4S (1195778-44-9)

Guidance literature:

C₁₀H₁₈NO₂S⁽¹⁺⁾*ClO₄^(1-); With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 3h; Inert atmosphere;

4-methoxy-benzaldehyde; In tert-butyl alcohol; at 20 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1039/b912070j

Reference yield:

D-methionine (348-67-4,26062-47-5,58576-49-1) → C18H25NO4S (1195778-44-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; iodine / tetrahydrofuran / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: camphor-10-sulfonic acid / Molecular sieve; Reflux; Inert atmosphere

3.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

4.1: sodium perchlorate / acetone / 40 °C / Inert atmosphere

5.1: sodium hydroxide / water; tert-butyl alcohol / 1 h / 25 °C / Inert atmosphere

5.2: 25 °C / Inert atmosphere

With sodium tetrahydroborate; camphor-10-sulfonic acid; sodium perchlorate; iodine; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1002/chem.201201332

Reference yield:

C10H18ClNO2S → C18H25NO4S (1195778-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium perchlorate / acetone / 40 °C / Inert atmosphere

2.1: sodium hydroxide / water; tert-butyl alcohol / 1 h / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With sodium perchlorate; sodium hydroxide; In water; acetone; tert-butyl alcohol;

DOI:10.1002/chem.201201332

upstream raw materials:

C₁₀H₁₈NO₂S⁽¹⁺⁾*ClO₄^(1-)

4-methoxy-benzaldehyde

D-methionine

(R)-2-amino-4-methylthio-1-butanol

Downstream raw materials:

[3-(4-methoxy-phenyl)-oxiranyl]-methanol

Refernces

• 1、 Sarabia, Francisco,Chammaa, Samy,Garcia-Castro, Miguel,Martin-Galvez, Francisca. "A highly efficient methodology of asymmetric epoxidation based on a novel chiral sulfur ylide". supporting information; experimental part. p. 5763 - 5765. Retrieved 2010/01/31.