(Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone

Base Information

• Chemical Name: (Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone
• CAS No.: 172371-89-0
• Molecular Formula: C₁₇H₁₄Cl₂N₂O
• Molecular Weight: 333.217
• Wikidata: Q76279066
• Mol file: 172371-89-0.mol

Synonyms:(Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone;172371-89-0;(3Z)-1-(2,6-dichlorophenyl)-3-(dimethylaminomethylidene)indol-2-one;(Z)-1,3-Dihydro-1-(2,6-dichlorophenyl)-3-((dimethylamino)methylene)-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-1-(2,6-dichlorophenyl)-3-((dimethylamino)methylene)-, (Z)-;LS-83780

Chemical Property of (Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone

Chemical Property:

• Vapor Pressure: 1.2E-08mmHg at 25°C
• Boiling Point: 460.1°Cat760mmHg
• Flash Point: 232°C
• PSA: 23.55000
• Density: 1.417g/cm³
• LogP: 4.63920
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 332.0483185
• Heavy Atom Count: 22
• Complexity: 456

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C=C1C2=CC=CC=C2N(C1=O)C3=C(C=CC=C3Cl)Cl
• Isomeric SMILES: CN(C)/C=C\1/C2=CC=CC=C2N(C1=O)C3=C(C=CC=C3Cl)Cl

Technology Process of (Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone

There total 1 articles about (Z)-1-(2',6'-Dichlorophenyl)-3-dimethylaminomethylene-2-indolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(2,6-dichlorophenyl)indolin-2-one (15362-40-0) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → 1-(2',6'-dichlorophenyl)-3-dimethylaminomethylene-2-indolinone (175983-50-3,172371-89-0)

Guidance literature:

In isopropyl alcohol; at 20 ℃; for 22h;

DOI:10.1007/BF02226519

Reference yield: 96.0%

2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) + 1-(2',6'-dichlorophenyl)-3-dimethylaminomethylene-2-indolinone (175983-50-3,172371-89-0) → 1-(2,6-Dichloro-phenyl)-3-[1-(1-methyl-2-phenyl-ethylamino)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one

Guidance literature:

for 6h;

DOI:10.1007/BF02226519

Reference yield: 73.0%

benzyl diazoacetate (52267-51-3) + 1-(2',6'-dichlorophenyl)-3-dimethylaminomethylene-2-indolinone (175983-50-3,172371-89-0) → benzyl 8-(2,6-dichlorophenyl)-8H-furo[2,3-b]indole-2-carboxylate

Guidance literature:

With indium(III) triflate; In 1,2-dichloro-ethane; for 6h; Reflux;

DOI:10.1021/acs.orglett.2c00019

upstream raw materials:

1-(2,6-dichlorophenyl)indolin-2-one

N,N-dimethylformamide diethyl diacetal

Downstream raw materials:

(Z)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone

(E)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone

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