Piperidine, hydrobromide

Base Information

• Chemical Name: Piperidine, hydrobromide
• CAS No.: 14066-85-4
• Molecular Formula: C5H11 N . Br H
• Molecular Weight: 166.061
• DSSTox Substance ID: DTXSID90161457
• Mol file: 14066-85-4.mol

Synonyms:piperidine hydrobromide;Piperidine, hydrobromide;14066-85-4;Piperidinium bromide;Piperidine HBr;piperidine;hydrobromide;Piperidinehydrobromide-P28327;C5H11N.BrH;DTXSID90161457;MFCD01700569;AKOS027425916;LS-115565;S11730

Chemical Property of Piperidine, hydrobromide

Chemical Property:

• Vapor Pressure: 28.3mmHg at 25°C
• Melting Point: 200-240 °C
• Boiling Point: 106.4°Cat760mmHg
• Flash Point: 4.4°C
• PSA: 12.03000
• Density: g/cm³
• LogP: 2.04680
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 165.01531
• Heavy Atom Count: 7
• Complexity: 30.9

Purity/Quality:

99% ^*data from raw suppliers

PiperidineHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNCC1.Br

Technology Process of Piperidine, hydrobromide

There total 31 articles about Piperidine, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-hydroxyphenyl)-2-(piperidin-1-yl)ethanone hydrobromide → 4-hydroxyphenylacetate (156-38-7) + piperidine hydrobromide (14066-85-4)

Guidance literature:

In aq. acetate buffer; pH=5.6; pH-value; Irradiation;

DOI:10.1021/acs.joc.5b01770

Reference yield: 78.0%

ethyl 3-bromo-3-(4-fluorophenyl)-2-oxopropanoate + piperidine hydrochloride (6091-44-7) → ethyl 1-(5-bromopentyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate + piperidine hydrobromide (14066-85-4)

Guidance literature:

In 1,4-dioxane; for 2h; Reflux;

DOI:10.1016/j.tet.2015.10.004

Reference yield: 66.0%

1-(cyclohex-1-en-1-yl)piperidine (2981-10-4) + ethyl 3-bromo-2-oxo-3-phenylpropionate (6476-17-1) → ethyl 1-(5-bromopentyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylate + piperidine hydrobromide (14066-85-4)

Guidance literature:

In 1,4-dioxane; for 2h; Reflux;

DOI:10.1016/j.tet.2015.10.004

upstream raw materials:

N-bromopiperidine

piperidine

3-bromo-1-phenylpropan-1-one

1-ethyl-2-bromo-pyridinium; bromide

Downstream raw materials:

1-phenyl-2-piperidin-1-yl-ethanone