1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE

Base Information

• Chemical Name: 1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE
• CAS No.: 610797-49-4
• Molecular Formula: C9H10BrFO
• Molecular Weight: 233.08
• Hs Code.: 2909309090
• Mol file: 610797-49-4.mol

Synonyms:1-bromo-4-fluoro-2-propan-2-yloxybenzene;

Chemical Property of 1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 3.37540
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

1-Bromo-4-fluoro-2-isopropoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE

There total 4 articles about 1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-iodo-propane (75-30-9) + 2-bromo-5-fluorophenol (147460-41-1) → 1-bromo-4-fluoro-2-isopropoxybenzene (610797-49-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield: 92.0%

isopropyl bromide (75-26-3) + 2-bromo-5-fluorophenol (147460-41-1) → 1-bromo-4-fluoro-2-isopropoxybenzene (610797-49-4)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating / reflux;

Reference yield:

2-bromo-5-fluorophenol (147460-41-1) → 1-bromo-4-fluoro-2-isopropoxybenzene (610797-49-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1016/j.bmcl.2007.04.098

upstream raw materials:

isopropyl bromide

2-bromo-5-fluorophenol

2-iodo-propane

2,4-difluorobromobenzene

Downstream raw materials:

4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

1-bromo-2-isopropoxy-4-methylthio-benzene

1-bromo-2-isopropoxy-4-benzylthiobenzene

4-[4-(4-fluoro-2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexylamine

Refernces

• 1、 Dirr, Ronan,Anthaume, Cyril,Désaubry, Laurent. "Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes". . p. 4588 - 4590. Retrieved 2008/09/21.
• 2、 -. "Piperidinyl substituted cyclohexane-1,4-diamines". Page/Page column 35. . Retrieved 2008/06/13.