1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester
• CAS No.: 1379657-81-4
• Molecular Formula: C₁₉H₂₃ClNO₃P
• Molecular Weight: 379.823

Synonyms:1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester

Chemical Property of 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester

Chemical Property:

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Technology Process of 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester

There total 3 articles about 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline (78317-78-9) + phosphonic acid diethyl ester (762-04-9) → 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester (1379657-81-4)

Guidance literature:

With tris(p-bromophenylammoniumyl) hexachloroantimonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c3ob42454e

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester (1379657-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; copper(l) iodide; ethylene glycol / isopropyl alcohol / 24 h / 90 °C / Schlenk technique; Inert atmosphere

2: 4,4-difluoro-8-phenyl-4-bora-3a,4a-diaza-s-indacene / methanol / 5 h / 20 °C / Irradiation

With 4,4-difluoro-8-phenyl-4-bora-3a,4a-diaza-s-indacene; potassium phosphate; copper(l) iodide; ethylene glycol; In methanol; isopropyl alcohol;

DOI:10.1039/c5cc03421c

Reference yield:

1-Chloro-4-iodobenzene (637-87-6) → 1,2,3,4-tetrahydro-2-(4-chlorophenyl)isoquinolin-1-yl-1-phosphonic acid diethyl ester (1379657-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; copper(l) iodide; ethylene glycol / isopropyl alcohol / 24 h / 90 °C / Schlenk technique; Inert atmosphere

2: 4,4-difluoro-8-phenyl-4-bora-3a,4a-diaza-s-indacene / methanol / 5 h / 20 °C / Irradiation

With 4,4-difluoro-8-phenyl-4-bora-3a,4a-diaza-s-indacene; potassium phosphate; copper(l) iodide; ethylene glycol; In methanol; isopropyl alcohol;

DOI:10.1039/c5cc03421c

upstream raw materials:

2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline

phosphonic acid diethyl ester

1,2,3,4-tetrahydroisoquinoline

1-Chloro-4-iodobenzene

Downstream raw materials:

2-(4-chlorophenyl)-3,4-dihydroisoquinolin-1(2H)-one

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