N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

Base Information

Chemical Name:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline
CAS No.:1266336-66-6
Molecular Formula:C₂₂H₂₉ClN₄O₂S
Molecular Weight:449.017
Hs Code.:

Synonyms:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

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Chemical Property of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

There total 12 articles about N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1266335-59-4
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(methylsulfonyl)-aniline

: 1266336-66-6
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1266336-66-6
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: hydrogen; quinoline / Lindlar catalyst / ethyl acetate / 0.67 h

3.1: diethylzinc / dichloromethane; diethyl ether / -20 °C / Inert atmosphere

3.2: 0.17 h / -20 °C / Inert atmosphere

3.3: 24 h / -20 - 0 °C / Inert atmosphere

4.1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; ethanol / 0.5 h / 2585.81 Torr

5.1: sodium periodate / dichloromethane; water / 0 °C

6.1: ethanol; sodium tetrahydroborate / 0.5 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

9.1: triethylamine / dmap / dichloromethane / 1.5 h / Inert atmosphere

10.1: sodium azide / 1,4-dioxane; water / 2 h / 100 °C

11.1: triphenylphosphine; water / tetrahydrofuran / 2 h / 20 - 40 °C

12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C

12.2: 17 h / 20 - 110 °C

13.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With quinoline; sodium tetrahydroborate; sodium periodate; n-butyllithium; sodium azide; ethanol; water; hydrogen; diethylzinc; sodium tris(acetoxy)borohydride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; trifluoroacetic acid; dmap; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3.1: Charette cyclopropanation;

Reference yield:

: 1192063-83-4
tert-butyl 4-{(1R,2S)-2-[(2R)-3-(benzyloxy)-2-hydroxy-propyl]cyclopropyl}piperidine-1-carboxylate

: 1266336-66-6
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-N-methyl-4-(methylsulfonyl)-aniline

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; ethanol / 0.5 h / 2585.81 Torr

2.1: sodium periodate / dichloromethane; water / 0 °C

3.1: ethanol; sodium tetrahydroborate / 0.5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

6.1: triethylamine / dmap / dichloromethane / 1.5 h / Inert atmosphere

7.1: sodium azide / 1,4-dioxane; water / 2 h / 100 °C

8.1: triphenylphosphine; water / tetrahydrofuran / 2 h / 20 - 40 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C

9.2: 17 h / 20 - 110 °C

10.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With sodium tetrahydroborate; sodium periodate; sodium azide; ethanol; water; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; trifluoroacetic acid; dmap; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;