(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate
CAS No.:934588-76-8
Molecular Formula:C₃₈H₄₈N₂O₁₀S₆
Molecular Weight:885.203
Hs Code.:

(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

Synonyms:(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

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Chemical Property of (4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

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Technology Process of (4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

There total 9 articles about (4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 934588-75-7
N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

: 98-59-9
p-toluenesulfonyl chloride

: 934588-76-8
(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

Guidance literature:: With pyridine; dmap; at 0 - 28 ℃; for 3.25h;
DOI:10.1021/jo0624389

Reference yield:

: 934588-71-3
N-(4-hydroxy-1-hydroxymethyl-butyl)-4-methyl-benzenesulfonamide

: 934588-76-8
(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / imidazole / dimethylformamide / 3.5 h / 0 - 28 °C

2: pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 0.739 g / sodium hydride / tetrahydrofuran / 3 h / 0 °C

4: 65 percent / benzyltriethylammonium tetrathiomolybdate / CH₂Cl₂ / 2 h / 28 °C

5: 86 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 3.25 h / 0 - 28 °C

6: 75 percent / pyridine; 4-(dimethylamino)pyridine / 3.25 h / 0 - 28 °C

With pyridine; 1H-imidazole; dmap; benzyltriethylammonium tetrathiomolybdate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0624389

Reference yield:

: 934588-73-5
(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

: 934588-76-8
(4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / benzyltriethylammonium tetrathiomolybdate / CH₂Cl₂ / 2 h / 28 °C

2: 86 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 3.25 h / 0 - 28 °C

3: 75 percent / pyridine; 4-(dimethylamino)pyridine / 3.25 h / 0 - 28 °C

With pyridine; dmap; benzyltriethylammonium tetrathiomolybdate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0624389