(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

Base Information

Chemical Name:(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane
CAS No.:934588-73-5
Molecular Formula:C₂₈H₃₅NO₃SSi
Molecular Weight:493.742
Hs Code.:

Synonyms:(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

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Chemical Property of (2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

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Technology Process of (2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

There total 6 articles about (2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934588-71-3
N-(4-hydroxy-1-hydroxymethyl-butyl)-4-methyl-benzenesulfonamide

: 934588-73-5
(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / imidazole / dimethylformamide / 3.5 h / 0 - 28 °C

2: pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 0.739 g / sodium hydride / tetrahydrofuran / 3 h / 0 °C

With pyridine; 1H-imidazole; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0624389

Reference yield:

: 934588-72-4
N-[(1S)-4-(1-tert-butyl-1,1-diphenylsilyl)oxy-1-(hydroxymethyl)butyl]-4-methyl-1-benzenesulfonamide

: 934588-73-5
(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 0.739 g / sodium hydride / tetrahydrofuran / 3 h / 0 °C

With pyridine; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0624389

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 934588-73-5
(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / thionyl chloride / 4 h / 0 - 28 °C

2: 83 percent / pyridine / 3 h / 0 - 28 °C

3: 90 percent / LiBH₄ / tetrahydrofuran / 12 h / 0 - 28 °C

4: 80 percent / imidazole / dimethylformamide / 3.5 h / 0 - 28 °C

5: pyridine / CH₂Cl₂ / 3 h / 20 °C

6: 0.739 g / sodium hydride / tetrahydrofuran / 3 h / 0 °C

With pyridine; 1H-imidazole; lithium borohydride; thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0624389