N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

Base Information

Chemical Name:N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide
CAS No.:934588-75-7
Molecular Formula:C₂₄H₃₆N₂O₆S₄
Molecular Weight:576.824
Hs Code.:

Synonyms:N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

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Chemical Property of N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

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Technology Process of N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

There total 8 articles about N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 934588-74-6
N-((1S)-4-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-1-[((2S)-5-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

: 934588-75-7
N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 28 ℃; for 3.25h;
DOI:10.1021/jo0624389

Reference yield:

: 934588-71-3
N-(4-hydroxy-1-hydroxymethyl-butyl)-4-methyl-benzenesulfonamide

: 934588-75-7
N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / imidazole / dimethylformamide / 3.5 h / 0 - 28 °C

2: pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 0.739 g / sodium hydride / tetrahydrofuran / 3 h / 0 °C

4: 65 percent / benzyltriethylammonium tetrathiomolybdate / CH₂Cl₂ / 2 h / 28 °C

5: 86 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 3.25 h / 0 - 28 °C

With pyridine; 1H-imidazole; benzyltriethylammonium tetrathiomolybdate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0624389

Reference yield:

: 934588-73-5
(2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane

: 934588-75-7
N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / benzyltriethylammonium tetrathiomolybdate / CH₂Cl₂ / 2 h / 28 °C

2: 86 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 3.25 h / 0 - 28 °C

With benzyltriethylammonium tetrathiomolybdate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0624389