1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

Base Information

Chemical Name:1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid
CAS No.:1332706-74-7
Molecular Formula:C₂₄H₁₉ClN₂O₃
Molecular Weight:418.879
Hs Code.:

Synonyms:1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

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Chemical Property of 1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

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Technology Process of 1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

There total 9 articles about 1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332707-02-4
methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

: 1332706-74-7
1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

Guidance literature:: methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate; With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; at 70 ℃; for 15h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride;

Reference yield:

: 335349-57-0
2-nitro-4-iodo-5-chloroaniline

: 1332706-74-7
1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 3 h / Reflux

3.1: potassium carbonate / acetone / 0 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

6.1: potassium carbonate / tetrahydrofuran / 20 h / 60 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

8.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 15 h / 70 °C / Inert atmosphere

8.2: 1 h / 20 °C

With potassium phosphate; 1,3-dimethylbarbituric acid; iron; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1332706-74-7
1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; N-iodo-succinimide / 50 °C

2.1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol / 3 h / Reflux

4.1: potassium carbonate / acetone / 0 - 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

7.1: potassium carbonate / tetrahydrofuran / 20 h / 60 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

9.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 15 h / 70 °C / Inert atmosphere

9.2: 1 h / 20 °C

With potassium phosphate; N-iodo-succinimide; 1,3-dimethylbarbituric acid; iron; potassium carbonate; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;