methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate
CAS No.:1332707-02-4
Molecular Formula:C₂₈H₂₅ClN₂O₃
Molecular Weight:472.971
Hs Code.:

Synonyms:methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

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Chemical Property of methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

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Technology Process of methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

There total 9 articles about methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332706-87-2
5-(biphenyl-4-yl)-6-chloro-2-(methylsulfonyl)-1-(prop-2-en-1-yl)-1H-benzimidazole

: 88157-42-0
methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate

: 1332707-02-4
methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 335349-57-0
2-nitro-4-iodo-5-chloroaniline

: 1332707-02-4
methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 3 h / Reflux

3: potassium carbonate / acetone / 0 - 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

6: potassium carbonate / tetrahydrofuran / 20 h / 60 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

With potassium phosphate; iron; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1332707-02-4
methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid; N-iodo-succinimide / 50 °C

2: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3: potassium hydroxide / ethanol / 3 h / Reflux

4: potassium carbonate / acetone / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

7: potassium carbonate / tetrahydrofuran / 20 h / 60 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

With potassium phosphate; N-iodo-succinimide; iron; potassium carbonate; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;