ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

Base Information

Chemical Name:ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate
CAS No.:1354491-70-5
Molecular Formula:C₂₁H₁₆BrClO₃
Molecular Weight:431.713
Hs Code.:

Synonyms:ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

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Chemical Property of ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

Chemical Property:

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Technology Process of ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

There total 3 articles about ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1354491-69-2
ethyl 2-(7-bromo-3-methyl-1-(trifluoromethylsulfonyloxy)naphthalen-2-yl)-2-oxoacetate

: 1679-18-1
4-Chlorophenylboronic acid

: 1354491-70-5
ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

: 1354491-71-6
ethyl 2-(1,7-bis(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; at 20 ℃; for 2h;

Reference yield:

: 1354491-68-1
ethyl 2-(7-bromo-3-methyl-1-(trifluoromethylsulfonyloxy)-naphthalen-2-yl)-2-hydroxyacetate

: 1354491-70-5
ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

: 1354491-71-6
ethyl 2-(1,7-bis(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 1.5 h

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 2 h / 20 °C

With potassium carbonate; Dess-Martin periodane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 1354491-91-0
ethyl 4-(4-bromophenyl)-3-methylbut-2-enoate

: 1354491-70-5
ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

: 1354491-71-6
ethyl 2-(1,7-bis(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-oxoacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 2.5 h / 50 °C

2.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 °C

2.2: 1.25 h / 0 °C

3.1: 1H-imidazole; triethylsilyl chloride / dichloromethane / 16 h

3.2: 0.5 h / -78 °C

3.3: 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1.5 h

5.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene; ethanol / 2 h / 20 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylsilyl chloride; sulfuric acid; titanium tetrachloride; potassium carbonate; Dess-Martin periodane; In ethanol; dichloromethane; water; toluene;