methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate

Base Information

• Chemical Name: methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate
• CAS No.: 128009-22-3
• Molecular Formula: C₂₄H₂₈O₈
• Molecular Weight: 444.482
• Mol file: 128009-22-3.mol

Synonyms:methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate

Chemical Property of methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate

There total 11 articles about methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β,4β-bis(3',4'-dimethoxyphenyl)-1α-carboxy-2α-<butyl>cylobutanecarboxamide → phenyl carbamate (64-10-8) + methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate (128009-22-3) + prenylagmatine

Guidance literature:

With sulfuric acid; In methanol;

DOI:10.1016/0960-894X(96)00007-8

Reference yield:

methanol (67-56-1) + 3β,4β-bis(3',4'-dimethoxyphenyl)-1α-carboxy-2α-<butyl>cylobutanecarboxamide → phenyl carbamate (64-10-8) + methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate (128009-22-3) + prenylagmatine

Guidance literature:

With sulfuric acid;

DOI:10.1016/0960-894X(96)00007-8

Reference yield:

ethyl (E)-3,4-dimethoxycinnamate (20583-78-2,24393-65-5) → methyl 3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylate (128009-22-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 40 percent / 6 h / Irradiation

2: 97 percent / KOH, aq. EtOH / 6 h

3: 30 percent / 1-cyclohexyl-3-(2-morpholimoethyl)carbodiimide (CMC) metho-p-toluenesulfonate / CH₂Cl₂ / 2 h / Ambient temperature

4: 61 percent / CH₃SO₃H / dioxane / 4 h / Heating

5: 158 mg / 2 N NaOH, MeOH / 96 h

6: 42 mg / 2 N H₂SO₄, MeOH / 3 h

With methanol; potassium hydroxide; sodium hydroxide; methanesulfonic acid; ethanol; sulfuric acid; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm991004l

upstream raw materials:

methyl 3,4-dimethoxycinnamate

diazomethane

3β,4β-bis(3',4'-dimethoxyphenyl)-1α,2α-cyclobutanedicarboxylic acid

methanol