8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline

Base Information

• Chemical Name: 8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline
• CAS No.: 444620-48-8
• Molecular Formula: C₁₆H₂₅N₃O₂S
• Molecular Weight: 323.459

Synonyms:8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of 8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline

Chemical Property:

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Technology Process of 8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline

There total 1 articles about 8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-bromo-isoquinoline (63927-22-0) → 8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline (444620-48-8)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOAc; BINAP; Pd(dba)2

2: H₂ / Pt

3: TFA

With hydrogen; sodium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; platinum;

DOI:10.1016/j.bmcl.2005.07.035

Reference yield:

8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline (444620-48-8) → (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-oxo-2-{4-[2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-8-yl]-piperazin-1-yl}-ethyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: HATU

2: H(+)

With hydrogen cation; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

DOI:10.1016/j.bmcl.2005.07.035

Reference yield:

8-piperazin-1-yl-2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline (444620-48-8) + (N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine (252008-71-2) → 3-(1-(4-chloro-benzyl)-2-oxo-2-{4-[2-(propane-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-8-yl]-piperazin-1-yl}-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

DOI:10.1016/j.bmcl.2005.07.035

upstream raw materials:

8-bromo-isoquinoline

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