2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro -, 2-(1,1-dimethylethyl) ester, (3R)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro -, 2-(1,1-dimethylethyl) ester, (3R)-
CAS No.:252008-71-2
Molecular Formula:C24H27ClN2O5
Molecular Weight:458.942
Hs Code.:

2(1H)-Isoquinolinecarboxylic acid,
3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro
-, 2-(1,1-dimethylethyl) ester, (3R)-

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro -, 2-(1,1-dimethylethyl) ester, (3R)-

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro -, 2-(1,1-dimethylethyl) ester, (3R)-

There total 8 articles about 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-carboxy-2-(4-chlorophenyl)ethyl]amino]carbonyl]-3,4-dihydro -, 2-(1,1-dimethylethyl) ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 766550-04-3
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

: 252008-71-2
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm0311285

Reference yield:

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 252008-71-2
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / TEA / ethyl acetate / 7 h / Heating

2: 96 percent / AcOH; HCl / dioxane / 1 h / 20 °C

3: 99 percent / HATU; DIEA / dimethylformamide / 2 h / 20 °C

4: 100 percent / aq. NaOH / methanol / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; TEA; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0311285