(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Base Information

Chemical Name:(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester
CAS No.:129122-44-7
Molecular Formula:C₄₄H₄₇FNO₅PSi
Molecular Weight:747.919
Hs Code.:

(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Synonyms:(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

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Chemical Property of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

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Technology Process of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

There total 16 articles about (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1608-51-1
4-fluorochalcone

: 129122-44-7
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; ammonium acetate; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 122253-00-3
4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

: 129122-44-7
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With n-butyllithium; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00113a019

Reference yield:

: 122252-56-6
β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid, ethyl ester

: 129122-44-7
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

3: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

4: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

5: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

6: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; ammonium acetate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019