ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Base Information

Chemical Name:ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate
CAS No.:95250-01-4
Molecular Formula:C₂₇H₂₃Cl₂NO₇
Molecular Weight:544.388
Hs Code.:

Synonyms:ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

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Chemical Property of ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

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Technology Process of ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

There total 5 articles about ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 92285-33-1
ethyl 6,7-dichloro-2,3-dihydro-5-<3-(aminomethyl)-4-hydroxybenzoyl>-2-benzofurancarboxylate hydrochloride

: 95250-01-4
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: With potassium hydrogencarbonate; In acetonitrile; for 1.5h;
DOI:10.1021/jm50001a009

Reference yield:

: 90246-55-2
6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid

: 95250-01-4
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / conc. H₂SO₄ / 24 h / Ambient temperature

2: 54 percent / conc. H₂SO₄ / 6 h / 10 - 15 °C

3: 58 percent / conc. aq. HCl / ethanol / 4 h / Heating

4: 92 percent / aq. KHCO₃ / acetonitrile / 1.5 h

With hydrogenchloride; sulfuric acid; potassium hydrogencarbonate; In ethanol; acetonitrile;
DOI:10.1021/jm50001a009

Reference yield:

: 95249-99-3
ethyl 6,7-dichloro-2,3-dihydro-5-(4-hydroxybenzoyl)-2-benzofurancarboxylate

: 95250-01-4
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / conc. H₂SO₄ / 6 h / 10 - 15 °C

2: 58 percent / conc. aq. HCl / ethanol / 4 h / Heating

3: 92 percent / aq. KHCO₃ / acetonitrile / 1.5 h

With hydrogenchloride; sulfuric acid; potassium hydrogencarbonate; In ethanol; acetonitrile;
DOI:10.1021/jm50001a009