N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

Base Information

Chemical Name:N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine
CAS No.:1228103-49-8
Molecular Formula:C₃₀H₃₈N₄O₂SSi
Molecular Weight:546.809
Hs Code.:

Synonyms:N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Property of N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

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Technology Process of N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

There total 8 articles about N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 110-91-8,99108-56-2
morpholine

: 1228103-48-7
4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

: 1228103-49-8
N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: With diisopropylamine; In toluene; Reflux;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1228103-49-8
N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 0 - 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 85 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 80 °C

4: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

5: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

6: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

7: diisopropylamine / toluene / Reflux

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium acetate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 3: |Suzuki Coupling;

Reference yield:

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 1228103-49-8
N-(3-(t-butyldimethylsiloxy)phenyl)-6-(4-(2-morpholinoethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 85 °C

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 80 °C

3: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

4: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

6: diisopropylamine / toluene / Reflux

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium acetate; sodium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;