4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Base Information

Chemical Name:4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate
CAS No.:1228103-48-7
Molecular Formula:C₂₇H₃₃N₃O₄S₂Si
Molecular Weight:555.794
Hs Code.:

Synonyms:4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Suppliers and Price of 4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

There total 7 articles about 4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1228103-47-6
2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

: 124-63-0
methanesulfonyl chloride

: 1228103-48-7
4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1228103-48-7
4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 0 - 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 85 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 80 °C

4: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

5: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

6: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium acetate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling;

Reference yield:

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 1228103-48-7
4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenethyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 85 °C

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 80 °C

3: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

4: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium acetate; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;