(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
CAS No.:1500076-57-2
Molecular Formula:C₂₀H₂₈F₃N₃O₅S
Molecular Weight:479.521
Hs Code.:

Synonyms:(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

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Chemical Property of (R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

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Technology Process of (R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

There total 7 articles about (R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1500076-56-1
(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

: 1500076-57-2
(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1256841-19-6
4-nitrophenyl thiomorpholine-4-carboxylate

: 1500076-57-2
(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

: 1500076-57-2
(R)-tert-butyl (4-(1,1-dioxidothiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300104