(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
CAS No.:1500076-56-1
Molecular Formula:C₂₀H₂₈F₃N₃O₃S
Molecular Weight:447.522
Hs Code.:

Synonyms:(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

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Chemical Property of (R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Chemical Property:

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Technology Process of (R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

There total 5 articles about (R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256841-19-6
4-nitrophenyl thiomorpholine-4-carboxylate

: 1500076-35-6
(R)-tert-butyl (4-amino-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

: 1500076-56-1
(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 14h;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

: 1500076-56-1
(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300104

Reference yield:

: 881995-73-9
3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

: 1500076-56-1
(R)-tert-butyl (4-(thiomorpholine-4-carboxamido)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C

With lithium borohydride; sodium azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300104