N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Base Information

Chemical Name:N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide
CAS No.:1384875-16-4
Molecular Formula:C₂₁H₃₀F₂N₆O₂S
Molecular Weight:468.571
Hs Code.:

Synonyms:N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Suppliers and Price of N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

There total 6 articles about N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858121-94-5
4-(bromomethyl)-1,1-difluorocyclohexane

: 74-96-4
ethyl bromide

: 1384875-65-3
4-(4-sulfamoyl-4,7-diazaspiro[2.5]oct-7-yl)-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester

: 1384875-15-3
N-[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-16-4
N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-17-5
N,N-bis[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: 4-(bromomethyl)-1,1-difluorocyclohexane; 4-(4-sulfamoyl-4,7-diazaspiro[2.5]oct-7-yl)-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 16h;

ethyl bromide; With caesium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 2h;

With 2,2,2-trifluoroethanol; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1384875-15-3
N-[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-16-4
N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-17-5
N,N-bis[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water / 16 h / 100 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

2.2: 0.25 h

3.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 45 °C

5.2: 2 h / 45 °C

5.3: 1 h / 100 °C

With ammonium formate; potassium carbonate; SULFAMIDE; caesium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1261358-78-4
4-(4-benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 1384875-15-3
N-[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-16-4
N-[(4,4-difluorocyclohexyl)methyl]-N-ethyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

: 1384875-17-5
N,N-bis[(4,4-difluorocyclohexyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

1.2: 0.25 h

2.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 45 °C

4.2: 2 h / 45 °C

4.3: 1 h / 100 °C

With ammonium formate; SULFAMIDE; caesium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;