O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate

Base Information

• Chemical Name: O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate
• CAS No.: 1408282-95-0
• Molecular Formula: C₂₁H₂₉N₃O₅S
• Molecular Weight: 435.544

Synonyms:O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate

Chemical Property of O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate

There total 4 articles about O-tert-butyl (R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-aminobutanoic acid (1408282-87-0) + O-(tert-butyl)hydroxylamine hydrochloride (39684-28-1) → O-tert-butyl (R)-N2-(4-methoxyphenylsulfonyl)-N2-(3-pyridylmethyl)-2-aminobutanehydroxamate (1408282-95-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2015.03.078

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → O-tert-butyl (R)-N2-(4-methoxyphenylsulfonyl)-N2-(3-pyridylmethyl)-2-aminobutanehydroxamate (1408282-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 48 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Sealed tube

4: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 4-methyl-morpholine; pyridine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.03.078

Reference yield:

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)aminobutanoate (1408282-64-3) → O-tert-butyl (R)-N2-(4-methoxyphenylsulfonyl)-N2-(3-pyridylmethyl)-2-aminobutanehydroxamate (1408282-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Sealed tube

3: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.03.078

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)aminobutanoate

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-aminobutanoate

(R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-aminobutanoic acid

Downstream raw materials:

(R)-N₂-(4-methoxyphenylsulfonyl)-N₂-(3-pyridylmethyl)-2-aminobutanehydroxamic acid

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