N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine

Base Information

• Chemical Name: N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine
• CAS No.: 166815-96-9
• Molecular Formula: C18H27NO5S
• Molecular Weight: 369.482
• Hs Code.: 2933399090
• European Community (EC) Number: 682-427-8
• DSSTox Substance ID: DTXSID50442916
• Nikkaji Number: J2.906.209I
• Wikidata: Q72509329
• ChEMBL ID: CHEMBL4978805
• Mol file: 166815-96-9.mol

Synonyms:166815-96-9;N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine;tert-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate;N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;1-Boc-4-(tosyloxymethyl)piperidine;tert-butyl 4-(tosyloxymethyl)piperidine-1-carboxylate;4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester;MFCD05864740;Tert-butyl 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylate;tert-butyl 4-({[(4-methylbenzene)sulfonyl]oxy}methyl)piperidine-1-carboxylate;tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate;tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine;1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine;1-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;tert-Butyl 4-({[(4-methylphenyl)sulfonyl]-oxy}methyl)piperidine-1-carboxylate;1-Boc-4-[(tosyloxy)methyl]piperidine;1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;SCHEMBL216692;CHEMBL4978805;4-tosyloxymethyl-n-boc-piperidine;DTXSID50442916;DARTVAOOTJKHQW-UHFFFAOYSA-N;BCP18431;STL357534;AKOS005174069;CS-W008172;AC-24627;AS-18148;SY045473;A3697;AM20060453;B4759;FT-0630182;EN300-54177;1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine;N-tert-butoxycarbonyl-4-tosyloxymethylpiperidine;1-(tert-Butoxycarbonyl)-4-tosyloxymethylpiperidine;3,5-Dimethyl-3,5-Di-tert-butyl-4,4-diphenoquinone;t-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate;F2167-0074;tert-butyl 4-[(tosyloxy)methyl]piperidin-1-carboxylate;Z808247530;1-(t-butoxycarbonyl)-4-(4-toluenesulphonyloxy)methylpiperidine;tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine;tert-Butyl 4-(p-tolylsulfonyloxymethyl)piperidine-1-carboxylate;4-(4-methylphenylsulphonyloxymethyl)-1-tert-butoxycarbonylpiperidine;4-(4-tolylsulphonyloxymethyl)-1-tert-butyloxycarbonyl-piperidine;4-[(Tosyloxy)methyl]piperidine-1-carboxylic acid tert-butyl ester;1-(tert-butoxycarbonyl)-4-(4 methylphenylsulphonyloxymethyl)piperidine;1-(tert-butoxycarbonyl)-4-(4-methylphenylsulfonyloxymethyl)piperidine;1-(tert-butoxycarbonyl)-4-(4-methylphenylsulphonyloxymethyl)piperidine;1-(tert-butoxycarbonyl)4-(4-methylphenylsulphonyloxymethyl)piperidine;1-(tertbutoxycarbonyl)-4-(4-methylphenylsulphonyloxymethyl)piperidine;4-(4-methylphenylsulphonyloxymethyl)-1-tert-butyloxycarbonylpiperidine;tert-Butyl 4-(4-methylbenzenesulfonyloxymethyl)piperidine-1-carboxylate;1,1-dimethylethyl 4-({[(4-methyl phenyl)sulfonyl]oxy}methyl)-1-piperidinecarboxylate;1,1-dimethylethyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1-piperidinecarboxylate;4-(toluene-4-sulfonyloxymethyl)-piperidine 1-carboxylic acid tert-butyl ester;4-(Toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-({[(4-methylphenyl)sulphonyl]oxy}methyl)piperidin-1-ylcarboxylate;tert-Butyl 4-{[(4-methylbenzene-1-sulfonyl)oxy]methyl}piperidine-1-carboxylate;1-Piperidinecarboxylicacid,4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-,1,1-dimethylethyl ester

Chemical Property of N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 74-76℃
• Refractive Index: 1.526
• Boiling Point: 487.784 °C at 760 mmHg
• PKA: -1.94±0.40(Predicted)
• Flash Point: 248.803 °C
• PSA: 81.29000
• Density: 1.175 g/cm³
• LogP: 4.36610
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 369.16099414
• Heavy Atom Count: 25
• Complexity: 533

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-((tosyloxy)methyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC2CCN(CC2)C(=O)OC(C)(C)C
• Uses: tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.

Technology Process of N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine

There total 9 articles about N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine (166815-96-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 17 ℃; for 2h; Inert atmosphere;

Reference yield: 88.0%

→ N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine (166815-96-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 85.0%

1,4-diaza-bicyclo[2.2.2]octane (280-57-9,88935-43-7) + 2-Methylpentane (107-83-5) + p-toluenesulfonyl chloride (98-59-9) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine (166815-96-9)

Guidance literature:

In diethyl ether; tert-butyl methyl ether;

upstream raw materials:

p-toluenesulfonyl chloride

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

4-piperidinemethanol

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 4-(fluoromethyl)piperidine-1-carboxylate

methyl 3-methoxy-4-(1-tert-butyloxycarbonylpiperidin-4-ylmethoxy)benzoate

4-[4-(3-nitrophenyl)piperazin-1-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester

methyl 3-methoxy-4-(1-methylpiperidin-4-ylmethoxy)benzoate