1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Base Information

Chemical Name:1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne
CAS No.:1398115-51-9
Molecular Formula:C₂₂H₂₄S
Molecular Weight:320.499
Hs Code.:

Synonyms:1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Suppliers and Price of 1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

There total 5 articles about 1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 882-33-7
diphenyldisulfane

: 119362-54-8
6-ethynyl-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene

: 1398115-51-9
1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Guidance literature:: 6-ethynyl-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

diphenyldisulfane; at 20 ℃;
DOI:10.1016/j.tetlet.2012.07.092

Reference yield:

: 1010385-76-8
2-methyl-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)but-3-yn-2-ol

: 1398115-51-9
1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / toluene / Reflux

1.2: 20 °C

2.1: n-butyllithium / tetrahydrofuran / -78 °C

2.2: 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetlet.2012.07.092

Reference yield:

: 27452-17-1
6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene

: 1398115-51-9
1-thiophenyl-2-[5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl]ethyne

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium dichloride; copper(l) iodide; triethylamine / methanol / 20 °C / Sonication

2.1: sodium hydride / toluene / Reflux

2.2: 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C

3.2: 20 °C

With copper(l) iodide; n-butyllithium; sodium hydride; triethylamine; palladium dichloride; In tetrahydrofuran; methanol; toluene; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tetlet.2012.07.092