(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

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Chemical Name:(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid
CAS No.:230961-06-5
Molecular Formula:C₃₄H₄₂N₂O₄
Molecular Weight:542.718
Hs Code.:

Synonyms:(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

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Chemical Property of (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

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Technology Process of (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

There total 12 articles about (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 230961-70-3
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoate

: 230961-06-5
(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 5002-26-6
3-methyl-4-phenylbromobenzene

: 230961-06-5
(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5 mol percent Pd(OAc)2*2P(o-tol)3; Et₃N / dimethylformamide / 100 °C

2: H₂ / 10 percent Pd/C / ethanol / 20 °C / 2250.18 Torr

3: HCl gas / CH₂Cl₂ / 0 °C

With hydrogenchloride; Pd(OAc)2[P(2-tolyl)3]2; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/S0960-894X(00)00720-4

Reference yield:

: 179533-97-2
(R)-2-(2-(tert-butoxy)-2-oxoethyl)pent-4-enoic acid

: 230961-06-5
(3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N'-dimethylaminopropylcarbodiimide; 7-aza-1-hydroxy-1,2,3-benzotriazole; N-methylmorpholine / CH₂Cl₂ / 18 h / 0 - 20 °C

2: 5 mol percent Pd(OAc)2*2P(o-tol)3; Et₃N / dimethylformamide / 100 °C

3: H₂ / 10 percent Pd/C / ethanol / 20 °C / 2250.18 Torr

4: HCl gas / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; Pd(OAc)2[P(2-tolyl)3]2; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1016/S0960-894X(00)00720-4