(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

Base Information

Chemical Name:(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione
CAS No.:1388167-49-4
Molecular Formula:C₂₃H₂₅ClN₄O₃
Molecular Weight:440.929
Hs Code.:

Synonyms:(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

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Chemical Property of (Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

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Technology Process of (Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

There total 3 articles about (Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 92-54-6
4-phenyl-1-piperazine

: 1388167-21-2
C₁₃H₁₁ClN₂O₃

: 1388167-49-4
(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

Guidance literature:: In dichloromethane; Microwave irradiation;
DOI:10.1016/j.bmc.2012.05.064

Reference yield:

: 10040-86-5,120697-22-5,109754-08-7
(Z)-5-(4-chlorobenzylidene)imidazolidine-2,4-dione

: 1388167-49-4
(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 0 °C

2: dichloromethane / Microwave irradiation

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.064

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1388167-49-4
(Z)-5-(4-chlorobenzylidene)-3-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; acetic acid / Reflux

2: triphenylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 0 °C

3: dichloromethane / Microwave irradiation

With sodium acetate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.064