(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

Base Information

Chemical Name:(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran
CAS No.:159691-06-2
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

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Chemical Property of (2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

Chemical Property:

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Technology Process of (2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

There total 7 articles about (2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 123-62-6
propionic acid anhydride

: 4-((2S,6R)-6-Aminomethyl-tetrahydro-pyran-2-yloxy)-benzoic acid propyl ester

: 159691-06-2
(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

Guidance literature:: With sodium hydrogencarbonate;
DOI:10.1021/ja00104a008

Reference yield:

: 3749-36-8
2-hydroxymethyl-3,4-dihydro-2H-pyran

: 159691-06-2
(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 28percent aq. NH₃ / various solvent(s) / 15 h / 110 °C

4: 100 percent / N,N-diethylisopropylamine / CH₂Cl₂ / 0.67 h / 0 °C

5: 69 percent / 3A molecular sieves, CF₃SO₃H / CH₂Cl₂ / 0.08 h / 0 °C

6: 100 percent / thiourea, 2,6-lutidine / ethanol / 1 h / 100 °C

7: 100 percent / aq. NaHCO₃

With 2,6-dimethylpyridine; ammonium hydroxide; N,N-diethyl-N-isopropylamine; trifluorormethanesulfonic acid; 3 A molecular sieve; sodium hydrogencarbonate; triethylamine; thiourea; In ethanol; dichloromethane;
DOI:10.1021/ja00104a008

Reference yield:

: 4781-76-4
(3,4-dihydro-2H-pyran-2-yl)methanamine

: 159691-06-2
(2S,6R)-2-<4'-<(carboxypropyl)oxy>phenoxy>-6-(propanamidomethyl)tetrahydropyran

Guidance literature:: Multi-step reaction with 5 steps

2: 100 percent / N,N-diethylisopropylamine / CH₂Cl₂ / 0.67 h / 0 °C

3: 69 percent / 3A molecular sieves, CF₃SO₃H / CH₂Cl₂ / 0.08 h / 0 °C

4: 100 percent / thiourea, 2,6-lutidine / ethanol / 1 h / 100 °C

5: 100 percent / aq. NaHCO₃

With 2,6-dimethylpyridine; N,N-diethyl-N-isopropylamine; trifluorormethanesulfonic acid; 3 A molecular sieve; sodium hydrogencarbonate; thiourea; In ethanol; dichloromethane;
DOI:10.1021/ja00104a008