methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

Base Information

• Chemical Name: methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester
• CAS No.: 1188542-36-0
• Molecular Formula: C₁₃H₁₄F₃NO₄S
• Molecular Weight: 337.32

Synonyms:methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

Chemical Property of methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

There total 4 articles about methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxymethyl-1-(3-trifluoromethylphenyl)pyrrolidin-2-one + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester (1188542-36-0)

Guidance literature:

3-hydroxymethyl-1-(3-trifluoromethylphenyl)pyrrolidin-2-one; With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

methanesulfonyl chloride; In dichloromethane; at 10 - 15 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

2-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid (174824-48-7) → methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester (1188542-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / 55 - 60 °C

2.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 1.5 h / 10 - 15 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester (1188542-35-9) → methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester (1188542-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

2.1: triethylamine / dichloromethane / 0.25 h / 0 °C

2.2: 1.5 h / 10 - 15 °C

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2016.11.007

upstream raw materials:

methanesulfonyl chloride

2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

3-trifluoromethylaniline

2-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Downstream raw materials:

8-{1-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

8-{1-[2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1188542-36-0 methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send