3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

Base Information

• Chemical Name: 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate
• CAS No.: 1613607-24-1
• Molecular Formula: C₄₈H₄₈N₄O₈
• Molecular Weight: 808.931
• Mol file: 1613607-24-1.mol

Synonyms:

Chemical Property of 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

There total 10 articles about 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-formyl-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate (1613414-01-9) → 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate (1613607-24-1)

Guidance literature:

Reference yield:

3-methoxybenzophenone (6136-67-0) → 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate (1613607-24-1)

Guidance literature:

Multi-step reaction with 10 steps

1: hydrogen bromide

2: water; ethanol; formamide

3: methanol

4: N-ethyl-N,N-diisopropylamine; potassium carbonate / methanol; ethyl acetate; dichloromethane; 2-Methylpentane

5: potassium carbonate / acetonitrile

6: hydrogenchloride / methanol; 1,4-dioxane

7: ethyl acetate; water; pyridine

8: hydrogenchloride; lithium hydroxide / tetrahydrofuran; ethanol

9: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; lithium hydroxide; hydrogen bromide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; 2-Methylpentane; dichloromethane; water; formamide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-hydroxybenzophenone (13020-57-0) → 3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate (1613607-24-1)

Guidance literature:

Multi-step reaction with 9 steps

1: water; ethanol; formamide

2: methanol

3: N-ethyl-N,N-diisopropylamine; potassium carbonate / methanol; ethyl acetate; dichloromethane; 2-Methylpentane

4: potassium carbonate / acetonitrile

5: hydrogenchloride / methanol; 1,4-dioxane

6: ethyl acetate; water; pyridine

7: hydrogenchloride; lithium hydroxide / tetrahydrofuran; ethanol

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; lithium hydroxide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; 2-Methylpentane; dichloromethane; water; formamide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3-methoxybenzophenone

3-hydroxybenzophenone

N-((3-hydroxyphenyl)(phenyl)methyl)formamide

3-(Amino(phenyl)methyl)phenol hydrochloride