tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS No.:1227473-03-1
Molecular Formula:C₂₀H₂₆F₃NO₃
Molecular Weight:385.427
Hs Code.:

Synonyms:tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

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Chemical Property of tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

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Technology Process of tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

There total 4 articles about tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1227473-02-0
tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]dec-3-ene-8-carboxylate

: 1227473-03-1
tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Guidance literature:: With hydrogen; Raney nickel; In methanol; for 4h; under 1034.32 Torr;

Reference yield:

: 954236-44-3
tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

: 1227473-03-1
tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0 °C

2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

3: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

With nickel(II) iodide; sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; isopropyl alcohol; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

: 240401-09-6
tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate

: 1227473-03-1
tert-butyl 3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

2: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

With nickel(II) iodide; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; isopropyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048