N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine

Base Information

• Chemical Name: N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine
• CAS No.: 1246766-88-0
• Molecular Formula: C₂₀H₂₀N₄O₅
• Molecular Weight: 396.403
• Mol file: 1246766-88-0.mol

Synonyms:N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine

Chemical Property of N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine

There total 3 articles about N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (10078-54-3) + 1-(2-methyl-5-nitrophenyl)guanidine nitrate (152460-08-7) → N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine (1246766-88-0)

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; at 90 ℃; for 24h;

DOI:10.1016/j.ejmech.2011.09.039

Reference yield:

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine (1246766-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 12 h / 20 °C / Reflux

2: sodium hydroxide / isopropyl alcohol / 24 h / 90 °C

With sodium hydroxide; In ethanol; isopropyl alcohol;

DOI:10.1016/j.ejmech.2011.09.039

Reference yield:

2-methyl-5-nitroaniline (99-55-8) → N-(5-nitro-2-methylphenyl)-4-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine (1246766-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nitric acid / ethanol / 0.17 h / 20 °C

1.2: 12 h / 80 - 85 °C

2.1: sodium hydroxide / isopropyl alcohol / 24 h / 90 °C

With nitric acid; sodium hydroxide; In ethanol; isopropyl alcohol;

DOI:10.1016/j.ejmech.2011.09.039

upstream raw materials:

3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

1-(2-methyl-5-nitrophenyl)guanidine nitrate

methyl (3,4,5-trimethoxyphenyl) ketone

2-methyl-5-nitroaniline

Downstream raw materials:

N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)biphenyl-4-sulfonamide

4-methoxy-N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)benzenesulfonamide

3,4-dimethoxy-N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)benzenesulfonamide

N-(4-methyl-3-(4-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino)phenyl)naphthalene-2-sulfonamide