(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Base Information

Chemical Name:(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol
CAS No.:1453852-14-6
Molecular Formula:C₁₅H₂₄ClFO₂Si
Molecular Weight:318.891
Hs Code.:

Synonyms:(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Suppliers and Price of (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

There total 6 articles about (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.3%

: 1453852-12-4
(S)-1-(4-chloro-3-fluorophenyl)propane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1453852-14-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453852-14-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 17 h / 50 - 100 °C

2: chloro-trimethyl-silane / 20 h

3: diisobutylaluminium hydride / toluene / 4 h / -78 - 20 °C

4: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 4.33 h / -20 °C / Molecular sieve

5: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

6: 1H-imidazole / dichloromethane / 1 h / 0 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; chloro-trimethyl-silane; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; decane; dichloromethane; toluene;

Reference yield:

: 1453852-10-2
((2R,3R)-3-(4-chloro-3-fluorophenyl)oxiran-2-yl)methanol

: 1453852-14-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

2: 1H-imidazole / dichloromethane / 1 h / 0 °C

With 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; dichloromethane;