(1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile

Base Information

• Chemical Name: (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile
• CAS No.: 885117-65-7
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.213
• Mol file: 885117-65-7.mol

Synonyms:(1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile

Chemical Property of (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile

There total 2 articles about (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (99984-61-9,70351-50-7) + 1,1-dibromomethane (74-95-3) → (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile (885117-65-7) + C12H10N2OHBr + 1'-methyl-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2-carbonitrile (895576-37-1,895576-36-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2007.05.009

Reference yield: 25.0%

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile (99984-61-9,70351-50-7) + 1,1-dibromomethane (74-95-3) → (1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile (885117-65-7) + 1'-methyl-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2-carbonitrile (895576-37-1,895576-36-0)

Guidance literature:

With sodium hydroxide; tetra-tert-butylammonium hydrogen sulfate; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/j.tet.2007.05.009

Reference yield: 65.0%

(1-methyl-3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)acetonitrile (885117-65-7) + methoxybenzene (100-66-3) → 2-(3-(4-methoxyphenyl)-1-methyl-2-oxoindolin-3-yl)acetonitrile

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 0.333333h;

DOI:10.1039/d0ob02461a

upstream raw materials:

(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile

1,1-dibromomethane