2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene

Base Information

• Chemical Name: 2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene
• CAS No.: 1450906-55-4
• Molecular Formula: C₁₆H₂₂O₂
• Molecular Weight: 246.349
• Mol file: 1450906-55-4.mol

Synonyms:2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene

Chemical Property of 2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene

Chemical Property:

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Technology Process of 2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene

There total 1 articles about 2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butyl-3-methoxymethyl-1-phenyl-cycloprop-2-ene-1-carboxylic acid methoxymethyl ester (1065330-27-9) + C17H22O3 → 2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene (1450906-55-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 2.16667h;

DOI:10.1055/s-0033-1338876

Reference yield: 62.0%

2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene (1450906-55-4) + allylmagnesium bromide (1730-25-2) → 3α-allyl-3β-butyl-2α-(hydroxymethyl)-1-methylene-2β-phenylcyclopropane

Guidance literature:

With copper(l) iodide; In diethyl ether; hexane; at 20 ℃; for 16h; diastereoselective reaction;

DOI:10.1055/s-0033-1338876

Reference yield: 53.0%

2-butyl-1-(hydroxymethyl)-1-phenyl-3-(methoxymethyl)cycloprop-2-ene (1450906-55-4) + methylmagnesium bromide (75-16-1) → 3β-butyl-2α-(hydroxymethyl)-3α-methyl-2-methylene-2β-phenylcyclopropane

Guidance literature:

With iron(III)-acetylacetonate; In diethyl ether; hexane; at 20 ℃; for 16h; Concentration; diastereoselective reaction;

DOI:10.1055/s-0033-1338876

upstream raw materials:

2-butyl-3-methoxymethyl-1-phenyl-cycloprop-2-ene-1-carboxylic acid methoxymethyl ester