diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

Base Information

Chemical Name:diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate
CAS No.:1446476-09-0
Molecular Formula:C₄₅H₄₉N₅O₁₄
Molecular Weight:883.909
Hs Code.:

Synonyms:diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

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Chemical Property of diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

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Technology Process of diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

There total 4 articles about diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.9%

: 1446476-08-9
diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis(phenylazanediyl))diacetate

: 20357-25-9
6-nitroveratraldehyde

: 1446476-09-0
diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

Guidance literature:: diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis(phenylazanediyl))diacetate; 6-nitroveratraldehyde; With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -10 ℃; for 7h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; for 1h;
DOI:10.1021/ic400465g

Reference yield:

: 62-53-3
aniline

: 1446476-09-0
diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dipotassium hydrogenphosphate; potassium iodide / acetonitrile / Reflux

2.1: dipotassium hydrogenphosphate; potassium iodide / acetonitrile / Reflux

3.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 7 h / -10 °C

3.2: 1 h

With 2,6-dimethylpyridine; dipotassium hydrogenphosphate; trimethylsilyl trifluoromethanesulfonate; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.1021/ic400465g

Reference yield:

: 7703-74-4
2,6-bis-(bromomethyl)pyridine

: 1446476-09-0
diethyl 2,2′-((pyridine-2,6-diylbis(methylene))bis((4-((4,5-dimethoxy-2-nitrophenyl)(hydroxy)methyl)phenyl)azanediyl))diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dipotassium hydrogenphosphate; potassium iodide / acetonitrile / Reflux

2.1: dipotassium hydrogenphosphate; potassium iodide / acetonitrile / Reflux

3.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 7 h / -10 °C

3.2: 1 h

With 2,6-dimethylpyridine; dipotassium hydrogenphosphate; trimethylsilyl trifluoromethanesulfonate; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.1021/ic400465g