[4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester

Base Information

• Chemical Name: [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester
• CAS No.: 130169-04-9
• Molecular Formula: C₂₁H₂₄N₄O₃
• Molecular Weight: 380.447

Synonyms:[4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester

Chemical Property of [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester

Chemical Property:

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Technology Process of [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester

There total 2 articles about [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2-methyl-6-methylmercapto-4-oxopyrimidine-5-carbonitrile (15908-63-1) → [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester (130169-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 23 deg C, 30 min, 2.) 4.5 h

2: 1,2-dimethoxy-ethane / 23 h / Heating

With sodium hydride; In 1,2-dimethoxyethane;

DOI:10.1021/jm00172a034

Reference yield:

4-benzylpyperidine (31252-42-3) + methyl 5-cyano-1,6-dihydro-2-methyl-4-(methylthio)-6-oxo-1-pyrimidineacetate (119896-61-6) → [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester (130169-04-9)

Guidance literature:

In 1,2-dimethoxyethane; for 23h; Heating;

DOI:10.1021/jm00172a034

Reference yield:

[4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester (130169-04-9) → [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid (119896-57-0)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 1.5h; Yield given;

DOI:10.1021/jm00172a034

upstream raw materials:

4-benzylpyperidine

methyl 5-cyano-1,6-dihydro-2-methyl-4-(methylthio)-6-oxo-1-pyrimidineacetate

3,4-dihydro-2-methyl-6-methylmercapto-4-oxopyrimidine-5-carbonitrile

Downstream raw materials:

[4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid

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