5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE

Base Information

• Chemical Name: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE
• CAS No.: 15908-63-1
• Molecular Formula: C₇H₇N₃OS
• Molecular Weight: 181.218
• Hs Code.: 2933599090
• Mol file: 15908-63-1.mol

Synonyms:5-Pyrimidinecarbonitrile,4-hydroxy-2-methyl-6-(methylthio)- (8CI)

Chemical Property of 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE

Chemical Property:

• PSA: 94.84000
• LogP: 0.67188
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-4-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE

There total 7 articles about 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

acetamidine hydrochloride (124-42-5) + methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate (3490-92-4) → 3,4-dihydro-2-methyl-6-methylmercapto-4-oxopyrimidine-5-carbonitrile (15908-63-1)

Guidance literature:

With hydrogenchloride; triethylamine; In ethanol; Heating;

Reference yield: 72.0%

acetic anhydride (108-24-7) + (E)-3-amino-2-cyano-3-(methylsulfanyl)acrylamide (107427-79-2,15908-60-8) → 3,4-dihydro-2-methyl-6-methylmercapto-4-oxopyrimidine-5-carbonitrile (15908-63-1)

Guidance literature:

for 2h; Heating;

Reference yield: 27.0%

2-cyano-3,3-bis(methylthio)acrylamide (17823-69-7) + thioacetamide (62-55-5) → 3,4-dihydro-2-methyl-6-methylmercapto-4-oxopyrimidine-5-carbonitrile (15908-63-1) + 5-cyano-2-methyl-4,4-bis(methylthio)-6-oxo-1,4,5,6-tetrahydropyrimidine (144584-44-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 96h; Ambient temperature;

DOI:10.3987/COM-92-6062

upstream raw materials:

acetamide

[Bis(methylthio)methylene]malononitrile

acetamidine hydrochloride

methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate

Downstream raw materials:

Pelrinone

3-amino-4-hydroxy-6-methyl-2-phenylpyrazolo<3,4-d>pyrimidine

4-anilino-2-methyl-6-methylthiopyrimidine-5-carbonitrile

6-o-anisidino-2-methyl-4-methylthiopyrimidine-5-carbonitrile

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