15908-63-1

Basic information

• Product Name: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE
• Synonyms: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE;2-methyl-4-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
• CAS NO: 15908-63-1
• Molecular Formula: C₇H₇N₃OS
• Molecular Weight: 181.22
• Mol File: 15908-63-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE(15908-63-1)
• EPA Substance Registry System: 5-CYANO-2-METHYL-6-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE(15908-63-1)

Safety Data

• Hazardous Substances Data: 15908-63-1(Hazardous Substances Data)

Upstream product

• 60-35-5 acetamide 
• 5147-80-8 [Bis(methylthio)methylene]malononitrile 
• 124-42-5 acetamidine hydrochloride 
• 3490-92-4 methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate 
• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 
• 17823-69-7 2-cyano-3,3-bis(methylthio)acrylamide 
• 62-55-5 thioacetamide 
• 143-37-3 acetamidine 
• 108-24-7 acetic anhydride 
• 107427-79-2 (E)-3-amino-2-cyano-3-(methylsulfanyl)acrylamide 

Downstream Products

• 1300726-95-7 ethyl 5-diamino-8-(4-fluorophenyl)-2-methyl-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidine-6-carboxylate 
• 1300726-96-8 C₁₇H₁₇ClN₄O₄ 
• 1300726-97-9 C₁₇H₁₇BrN₄O₄ 
• 677733-07-2 C₁₂H₉ClN₄O 
• 130169-03-8 [4-(4-Benzyl-piperazin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester 
• 119896-53-6 [4-(4-Benzyl-piperazin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid 
• 130169-04-9 [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester 
• 119896-57-0 [4-(4-Benzyl-piperidin-1-yl)-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid 
• 130169-02-7 (4-Benzylamino-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl)-acetic acid methyl ester 
• 130196-51-9 [5-Cyano-4-(cyclohexylmethyl-amino)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid methyl ester 
• 119896-56-9 (4-Benzylamino-5-cyano-2-methyl-6-oxo-6H-pyrimidin-1-yl)-acetic acid 
• 119896-55-8 [5-Cyano-4-(cyclohexylmethyl-amino)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-acetic acid 
• 118996-66-0 6-o-anisidino-2-methyl-4-methylthiopyrimidine-5-carbonitrile 
• 118996-65-9 4-anilino-2-methyl-6-methylthiopyrimidine-5-carbonitrile 

Relevant articles and documents

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Chemotherapeutic agents: Part XXIII - Synthesis of π-deficient pyrimidines and fused pyrimidines as leishmanicides

Various ?-deficient pyrimidines and fused purimidines have been synthesized and evaluated for their leishmanicidal activity against L. donovani.

Synthesis of Pyrimidine Derivatives by the Reaction of Ketene Dithioacetals with Amides

Reactions of methyl 2-cyano-3,3-bis(methylthio)acrylate (1a) with carboxamides 2a-g in the presence of sodium hydride in a mixture of benzene and N,N-dimethylacetamide took place displacement with the methylthio group to give the corresponding methyl 3-N-acylamino-2-cyano-3-(methylthio)acrylates 3a-g which were readily converted to the corresponding pyrimidine derivatives at reflux in methanol in good yields.Reactions of 2-cyano-3,3-bis(methylthio)acrylonitrile (1b) with the carboxamides 2a-f gave directly pyrimidine-5-carbonitrile derivatives 7a-f.Ketene dithioacetals 1a,b smoothly reacted with thioamide 2g or urea 2h,i to give the expected pyrimidine derivatives 9,10a,b.Polyfunctionalized pyrimidines, thus obtained, were also used for the synthesis of fused pyrimidine derivatives.