3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Base Information

Chemical Name:3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol
CAS No.:1352571-41-5
Molecular Formula:C₂₆H₂₄N₂O₆S
Molecular Weight:492.552
Hs Code.:

Synonyms:3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

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Chemical Property of 3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

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Technology Process of 3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

There total 8 articles about 3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 1352571-40-4
5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)benzene-1,3-diol

: 1352571-41-5
3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; Sealed tube;

Reference yield:

: 108-46-3
recorcinol

: 1352571-41-5
3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / dichloromethane / -40 - 20 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 16 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; 3: Suzuki Coupling;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-41-5
3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / toluene / 2.5 h / -25 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 2: Suzuki Coupling;