Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

Base Information

Chemical Name:Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate
CAS No.:925441-77-6
Molecular Formula:C₂₆H₂₄O₈
Molecular Weight:464.472
Hs Code.:

Synonyms:Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

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Chemical Property of Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

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Technology Process of Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

There total 3 articles about Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 925441-73-2
Benzyl (9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

: 75-03-6
ethyl iodide

: 925441-77-6
Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

Guidance literature:: Benzyl (9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

ethyl iodide; In N,N-dimethyl-formamide; for 3h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 925441-37-8
(9aS)-8-Acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylic acid

: 925441-77-6
Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 3 h

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 925441-31-2
(9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide

: 925441-77-6
Benzyl (9aS)-8-acetyl-1-ethoxy-7-hydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water; sodium nitrite / acetonitrile / 4 - 15 h / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 3 h

With dmap; sulfuric acid; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;