1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

Base Information

Chemical Name:1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine
CAS No.:197079-40-6
Molecular Formula:C₂₀H₃₁NO₃Si
Molecular Weight:361.557
Hs Code.:

Synonyms:1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

Chemical Property:

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Technology Process of 1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

There total 1 articles about 1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 197079-39-3
(S)-benzyl 2-(tert-butyldimethylsilyloxy)methyl-4-oxo-pyrrolidine-1-carboxylate

: 197079-40-6
1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.10.057

Reference yield: 51.0%

: 95080-93-6
ethyl chlorooximidoacetate

: chlorooxime

: 197079-40-6
1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

: 7-benzyloxycarbonyl-8-t-butyldimethylsilyloxy-methyl-3-ethoxycarbonyl-1-oxa-2,7-diazaspiro-[4,4]-non-2-ene

Guidance literature:: With triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 197079-40-6
1-benzyloxycarbonyl-2(S)-t-butyldimethylsilyloxymethyl-4-methylenepyrrolidine

: (5R,8S)-8-Formyl-1-oxa-2,7-diaza-spiro[4.4]non-2-ene-3,7-dicarboxylic acid 7-benzyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂

2: aq. AcOH / tetrahydrofuran

3: (COCl)2; DMSO

With oxalyl dichloride; TEA; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 3: Swern oxidation;
DOI:10.1016/j.bmcl.2003.10.057