Technology Process of 1-Pyrrolidinecarboxylic acid,
2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxo-, phenylmethyl
ester, (2S)-
There total 11 articles about 1-Pyrrolidinecarboxylic acid,
2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxo-, phenylmethyl
ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide;
In
dichloromethane; water;
at 0 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/jacs.1c03529
- Guidance literature:
-
With
triethylamine;
In
dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / tetrahydrofuran; water / 7 h / 23 °C / Inert atmosphere
2: sulfuric acid / 12 h / Reflux; Inert atmosphere
3: lithium chloride; sodium tetrahydroborate / tetrahydrofuran; water / 22 h / 17 - 23 °C / Inert atmosphere
4: triethylamine / toluene / 18 h / 60 °C / Inert atmosphere
5: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane; water / 2.5 h / 0 °C / Inert atmosphere
With
sodium hypochlorite; sodium tetrahydroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; sodium hydrogencarbonate; triethylamine; lithium chloride; potassium bromide;
In
tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jacs.1c03529
