5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Base Information

• Chemical Name: 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• CAS No.: 173034-14-5
• Molecular Formula: C₁₉H₁₈ClN₃O₂
• Molecular Weight: 355.824

Synonyms:5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Chemical Property of 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

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Technology Process of 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

There total 3 articles about 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-fluoro-5-chloronitrobenzene (345-18-6) + 2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (19686-05-6) → 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (173034-14-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(95)01812-V

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (173034-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / TFA / ethanol

2: 88 percent / Cs₂CO₃ / dimethylformamide

With caesium carbonate; trifluoroacetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(95)01812-V

Reference yield:

N-4-methylphenylhydrazine (539-44-6) → 5-(4-Chloro-2-nitro-phenyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (173034-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / TFA / ethanol

2: 88 percent / Cs₂CO₃ / dimethylformamide

With caesium carbonate; trifluoroacetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(95)01812-V

upstream raw materials:

2-fluoro-5-chloronitrobenzene

2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

1-Methyl-4-piperidone

N-4-methylphenylhydrazine

Downstream raw materials:

N-[5-Chloro-2-(2,8-dimethyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-phenyl]-hydroxylamine

5-Chloro-2-(2,8-dimethyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-phenylamine

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