(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

Base Information

Chemical Name:(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate
CAS No.:1355611-34-5
Molecular Formula:C₂₃H₂₆N₂O₂S
Molecular Weight:394.538
Hs Code.:

Synonyms:(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

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Chemical Property of (E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

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Technology Process of (E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

There total 2 articles about (E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1236108-91-0
benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

: 4392-24-9
Cinnamyl bromide

: 1355611-34-5
(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

Guidance literature:: benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Cinnamyl bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 - 20 ℃; for 4h;
DOI:10.1021/jo201753q

Reference yield:

: 56414-65-4
1-(2-benzyloxycarbonylamino-1-oxo-ethyl)-pyrrolidine

: 1355611-34-5
(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Lawessons reagent; sodium hydrogencarbonate / toluene / 3 h / 120 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 4 h / -78 - 20 °C

With Lawessons reagent; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo201753q