benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

Base Information

Chemical Name:benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate
CAS No.:1236108-91-0
Molecular Formula:C₁₄H₁₈N₂O₂S
Molecular Weight:278.375
Hs Code.:

Synonyms:benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

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Chemical Property of benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

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Technology Process of benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

There total 1 articles about benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 56414-65-4
1-(2-benzyloxycarbonylamino-1-oxo-ethyl)-pyrrolidine

: 1236108-91-0
benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

Guidance literature:: With Lawessons reagent; sodium carbonate; In toluene; at 120 ℃; for 3h;
DOI:10.1016/j.tetlet.2010.04.102

Reference yield: 82.0%

: 1117-71-1
methyl 4-bromocrotonate

: 1236108-91-0
benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

: methyl-2-(1-(benzyloxycarbonylamino)-2-(pyrrolidin-1-yl)-2-thioxoethyl)but-3-enoate

Guidance literature:: methyl 4-bromocrotonate; benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate; With ferric(III) bromide; In acetonitrile; at 45 - 50 ℃; Inert atmosphere;

With triethylamine; In tetrahydrofuran; toluene; at -78 - 45 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.04.102

Reference yield: 74.0%

: 1236108-91-0
benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate

: 4392-24-9
Cinnamyl bromide

: 1355611-34-5
(E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate

Guidance literature:: benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Cinnamyl bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 - 20 ℃; for 4h;
DOI:10.1021/jo201753q